Background and aims: Amyotrophic lateral sclerosis (ALS) is one of the diseases which has been ascribed to overexposure to heavy metals and the metalloid selenium, but few data are still available on this issue, including the involvement of a specifies Selenium species, which have very different biological activities. Using an advanced analytical methodology, we designed a case-control study to test the association between selenium species and heavy metals with ALS risk, using as biomarker of exposure their concentrations in cerebrospinal fluid.
Poster: Selenium species and heavy metals in cerebrospinal fluid and risk of amyotrophic lateral sclerosis: a hospital-based case-control study